L eprosyor also called Morbus Hansen is a chronic infectious disease caused by the bacteria Mycobacterium leprae, through the skin and nasal mucosa. The disease of leprosy was included in one of the chronic infectious disease that is the number of occurrence is still high in the developing countries especially in the tropical regions. Throughout the year 2013, the Ministry of health of Indonesia noted the new leprosy cases 16,825, 6.82 per disability with numbers 1 million inhabitants. East Java was ranked first in Indonesia as the province with the highest leprosy cases about 30% of the total cases of leprosy in Indonesia. Leprosy disease poses complex problems, in terms of medical, social and economic consequences of bad stigma against leprosy sufferers community. This research aims to know the relationship between the knowledge of families with support for cured leprosy. The design of the research used in this study was observational analysis with cross-cut approach or cross sectional. Research conducted during the month of March – July 2018. The subject in this study is of a patient 74 leprous Sitanala Leprosy Hospital, Tangerang. Data were collected through questionnaires including knowledge, family support for recovery. Data analysis was done using statistics programs with test Chi Square value of significance of <0.05. The results of this study stated that the respondents with a good knowledge were 47 respondents (63.5%) and family support there is more on the patient with the family that supports as much as 58 respondents (78.4%). From the results of the statistical test of Chi-square who assess the relationship between the knowledge of families with support for cured leprosy patients obtained a value of p (p value) of 0000. These values were below the limit of significance of 0.05 means there is a correlation between the knowledge of families with support for cured leprosy patients. There is a relationship between the knowledge of families with support for cured leprosy patients.