Hubungan d-dimer terhadap derajat keparahan Covid-19 di RS Yos Sudarso

DETAIL KOLEKSI

Hubungan d-dimer terhadap derajat keparahan Covid-19 di RS Yos Sudarso

Oleh : Anantisia Arum Pratikno

Info Katalog

Nomor Panggil : S 2109

Penerbit : FK - Usakti

Kota Terbit : Jakarta

Tahun Terbit : 2023

Pembimbing 1 : Adrianus Kosasih

Subyek : COVID-19 (Diasese)

Kata Kunci : COVID-19, D-dimer, severity of COVID-19 cases

Status Posting : Published

Status : Lengkap

File Repositori

No.	Nama File	Hal.
1.	2023_TA_SKD_030001800010_Halaman-Judul.pdf	15
2.	2023_TA_SKD_030001800010_Pengesahan.pdf	1
3.	2023_TA_SKD_030001800010_BAB-1_Pendahuluan.pdf	4
4.	2023_TA_SKD_030001800010_BAB-2_Tinjauan-Literatur.pdf	12
5.	2023_TA_SKD_030001800010_BAB-3_Kerangka-Teori.pdf	3
6.	2023_TA_SKD_030001800010_BAB-4_Metode-Penelitian.pdf	7
7.	2023_TA_SKD_030001800010_BAB-5_Hasil.pdf	2
8.	2023_TA_SKD_030001800010_BAB-6_Pembahasan.pdf	6
9.	2023_TA_SKD_030001800010_BAB-7_Kesimpulan.pdf	1
10.	2023_TA_SKD_030001800010_Daftar-Pustaka.pdf	5
11.	2023_TA_SKD_030001800010_Lampiran.pdf	10

Abstrak
Abstract

S evere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) merupakan penyebab Coronavirus Disease 2019 (COVID-19). Manifestasi klinis dari COVID-19 didominasi oleh gejala respiratorik, namun infeksi COVID-19 juga dapat menyebabkan gangguan di luar paru, yaitu peradangan sistemik, penyakit tromboemboli atau gangguan koagulasi pembuluh darah seperti Deep Vein Thrombosis (DVT). D-dimer merupakan hasil dari degradasi fibrin yang terbentuk selama proses degradasi pembekuan darah oleh fibrinolisis. Adanya peningkatan pada D-dimer dapat menjadi indikator awal terjadinya tormbosis. Peningkatan nilai D-dimer pada pasien COVID-19 menjadi prediktor terjadinya Acute Respiratory Distress Syndrome (ARDS), kebutuhan perawatan di ruang intensif, dan bahkan kematian. Penelitian ini dilakukan untuk mengetahui hubungan D-dimer terhadap derajat keparahan COVID-19. Analisis observasional analitik dengan desain studi potong silang dengan rekam medis 108 pasien yang positif pada tes RT-PCR COVID-19 di RS Yos Sudarso pada bulan Januari-Desember 2021 yang berumur 19â€“58 tahun dan tanpa trombosis vena dalam, emboli paru, thrombosis arteri, DIC, kanker, dan penyakit liver kronis atau sedang dalam masa kehamilan. Variabel yang diteliti adalah D-dimer dan berat kasus COVID-19. Analisis data menggunakan uji Chi-square dan diolah dengan SPSS edisi 27 dengan tingkat kemaknaan 0,05. Hasil analisis antara D-dimer dengan berat kasus COVID-19 mendapatkan p-value 0,000 sehingga dapat disimpulkan bahwa terdapat hubungan antara berat kasus COVID-19 dengan D-dimer. Terdapat hubungan antara D-dimer dengan berat kasus COVID-19.

S evere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of Coronavirus Disease 2019 (COVID-19). The clinical manifestations of COVID-19 are predominantly respiratory symptoms, but also caused extrapulmonary disorders such as systemic inflammation, thromboembolic diseases, or vascular coagulation disorders like Deep Vein Thrombosis (DVT). D-dimer is a product of fibrin degradation that occurs during the process of blood coagulation breakdown by fibrinolysis. Increased levels of D-dimer can serve as an early indicator of thrombosis. Elevated D-dimer values in COVID-19 patients are predictors of Acute Respiratory Distress Syndrome (ARDS), the need for intensive care treatment, and even death. This study was conducted to determine the relation between D-dimer and the severity of COVID-19. Analytical observational analysis with cross-sectional study design performed using medical records of 108 patients who tested positive for COVID-19 via RT-PCR at Yos Sudarso Hospital from January to December 2021. The patients included in the study aged 19â€“58 years and had no history of deep vein thrombosis, pulmonary embolism, arterial thrombosis, disseminated intravascular coagulation (DIC), cancer, chronic liver disease, or currently pregnant. The variables investigated were age and the severity of COVID-19 cases. Data analysis was conducted using the Chi-square test and processed using SPSS 27th edition with significance level of 0.05. The analysis results of D-dimer and the severity of COVID-19 cases yielded a p-value of 0.000, suggesting that there is a relationship between the severity of COVID-19 cases and D-dimer. It is found that there was a relationship between D-dimer and the severity of COVID-19 cases.