S ince it was determined to be a human-to-human transmission, the coronavirus-2019 (COVID-19) infection which causes Severe Acute Respiratory Syndrome -Coronavirus 2 (SARS-Cov-2) is currently a pandemic in almost all countries in theworld. This pandemic outbreak has had a negative impact on the physical andpsychological health of individuals and communities. Experts point out that peoplewho are already suffering from psychiatric problems and who have not sufferedfrom the same risk. Along with the risk of infection, the COVID-19 pandemic isincreasing a source of stress for healthcare workers. As many as 55% of healthcareworkers in Indonesia are experiencing work related-stress due to the COVID-19pandemic. Exposure to stressors in the workplace is believed to trigger stress amonghealth workers. Several factors such as increased workload, low social support, lackof skills, organizational conflicts and problems, and emotional reactions to afflictedpatients contribute to work stress in healthcare professionals. This stress canundermine professional effectiveness, thereby reducing attention, weakeningdecision-making skills, reducing concentration, and negatively affecting the abilityof healthcare professionals to build professional relationships with their patients.Social support contributes to reducing stress on healthcare workers because it canincrease self confidence which leads to more understanding, respect,encouragement, courage, and a professional attitude. There are still very few studiesin Indonesia that discuss how to deal with work related-stress in healthcare workersso the purpose of this literature review is to discuss mechanisms to reduce workrelated-stess on healthcare workers so the health of healthcare workers aremaintained and improve the quality of life of healthcare workers. This literaturesearch uses databases including Google Scholar, Pubmed, and Science Direct whichdiscuss coping mechanisms to deal with work related-stress in healthcare workersduring the COVID-19 pandemic.