D iabetes mellitus is one of the most common systemic diseases occurs and has assigned it at the forefront of current public health challenges. The prevalence increased from year to year by leaps and bounds. Early diagnosis is necessary to suppress the rate of enhancement people with diabetes mellitus. Relation between blood glucose and salivary glucose level in people with diabetes mellitus should be observed thoroughly. In addition to scientific interest, it also aims that the people suffered this disease may have healthy and safety living. This research used people suffered diabetes mellitus type II as research subject, as many as 11 people. Blood glucose and salivary glucose level are calculated by using sudden method. The calculation of salivary glucose level is similar to the calculation of blood glucose level. Photometer instrument used is Rayto. Statistical analysis shows that there are significant differences of blood glucose and salivary glucose among people with diabetes mellitus and normal, and there is a correlation between blood glucose and salivary glucose value in diabetes mellitus. The conclusions are there are significant differences and correlations between blood glucose and salivary glucose among people with diabetes mellitus. The other conclusion in normal people there is significant difference between blood glucose and salivary glucose but there is no difference correlation in blood glucose and salivary glucose value.