T halassemia beta major is a hereditary hemolytic anemia disease with various grades of severity, which can be found with no or less globin chain qualitative synthesis. The patients often experiences growth retardation and bone disorder caused by bone marrow hyperplasia. The face and head of thalassemia beta major patients show a typical form known as facies thalassemia or chipmunk face. Excessive growth of maxilla, the dentition shows protrusion, large overjet, open bite anterior that leads to malocclusion, and abnormalities found in patients are skeletal class II malocclusion. The purpose of this paper is to determine the orthodontic treatment that applicable for improving the quality of life of thalassemia beta major patients. Orthodontic treatment can be done by using a functional appliance, fixed appliance, and combination of orthodontic surgery. The orthodontic treatment of thalassemia beta major shall be conducted as early as possible to prevent more severe malocclusion and in the shortest period possible right after the patient received a blood transfusion. The dentists, especially orthodontic specialists who treat patients with thalassemia beta major are expected to be aware of the importance of properly diagnosing and examination for yielding an appropriate treatment plan.