T he problem of tooth loss in Indonesia is still in the highest order, so it needs to be overcome by the use of dentures which need to be kept clean, if not plaque will increase. Plaque is an important factor that causes inflammation of the mucosa and facilitates C. albicans colonies to breed in that place so that candida infection can occur. The denture cleaning method can use mechanical / chemical methods, but tends to be expensive and there are still side effects cause by those methods. Therefore, there are still efforts to find ingredients that are more effective as removable denture cleansers. This Study aims to determine the effectiveness of red galangal rhizome extract in inhibiting the growth of C. albicans on acrylic resin plates. This study was a laboratory experimental study conducted by immersing acrylic resin plates previously exposed to C. albicans in red galangal rhizome extract, BHI broth, and 0.5% sodium hypochlorite with two immersion times which are 8 hours and 15 minutes. After that, colony counting (CFU / ml) were carried out. The Result of the Study shows that at the time of immersion 8 hours and 15 minutes, there were significant differences between the concentrations of red galangal rhizome extract with negative control. Concentration of 100%, 50%, 25%, and 12.5% red galangal rhizome extract of immersion time 8 hours is equivalent to positive control. Concentration of 100%, 50%, 25% red galangal rhizome extract of immersion time 15 minutes is equivalent to positive control. This Study concludes that red galangal rhizome extract at both 8-hour and 15-minute immersion times effectively inhibits the growth of C. albicans on acrylic resin plates.