T he high level of public awareness regarding aesthetic valuesinfluences the evolution and selection of restoration materials. Nanofillercomposite resin is an option in aesthetic restoration, because it has good aestheticqualities, mechanical properties and high wear resistance. Color changes thatoccur in nanofiller composite resin are undesirable, because they disturb theaesthetic value and appearance. Color changes in restoration materials areinfluenced by the acidic pH contained in artificial saliva. Objective: This studyaims to determine the effect of artificial saliva with a pH of 5 on the color changeof nanofiller composite resin restoration materials. Method: The research objectis a nanofiller composite resin with a diameter of 10 mm, a thickness of 2 mm.The research was carried out by soaking nanofiller composite resin in artificialsaliva and distilled water solution. The study was divided into 2 groups, namelythe treatment group and the control group. Which is placed in an incubator at atemperature of 37Ëš C for 24 hours. In the control group, samples were soaked indistilled water for 24 hours, repeated for 7 days. In the treatment group, sampleswere soaked in artificial saliva for 4 hours, repeated for 7 days, followed byimmersion in distilled water. The color parameters of the research subjects weremeasured using a Vita Easyshade V spectrophotometer before and afterimmersion in the control and treatment groups on the 7th day. The measurementresults data after carrying out the normality test, T test (dependent), and Wilcoxontest. Results: The results of this study showed a significant color change (p<0.05).Conclusion: There is an effect of artificial saliva with a pH of 5 on the colorchange of the nanofiller composite resin material.