P anoramic radiography technique has been known for its accuracy in the calculation of anthropometric in human and frequently used in dentistry. Using the morphometric analysis, panoramic radiograph can be used to determine gender with mandible foramen as the reference point because of its stable relation with some landmarks at mandible bone. Therefore, the aim of this study was to find out the difference of mandible foramen location based on sex differences reviewed with panoramic radiograph. The type of research is analytic observasional comparative with the sample consisted of 80 male and female panoramic radiograph, measured to three ramus of mandible anatomical landmarks, those are mandibular notch (C line), anterior border of mandible (A line) and posterior border of mandible (B line). The analysis result shows the mean distance of A line in male is 11.44 mm and 10.78 mm in female with p value =0.061. The mean distance of B line in male is 11.73 mm and 10.61 mm in female with p value =0.005. And the mean distance of C line in male is 14,95 mm and 12,90 mm in female with p value =0.003. that the vertical (mandibular notch) and horizontal posterior (posterior border of mandible) measurement p-value is <0,05. Therefore, it can be stated that there is significant difference due to gender in the location of mandible foramen vertically and horizontally posterior, and there is no significant difference in the distance of horizontally anterior.