D omestic wastewater is used water that can no longer be used for its originalpurpose, either containing human waste (feces) or from kitchen, bathroom andwashing activities. In handling wastewater, there is a need for further treatment ofeffluent that still does not meet wastewater quality standards. The combination ofSubsurface Constructed Wetland (SCW) and multi-layer filtration is an engineeringsystem that has been designed and built to utilize natural processes, can be analternative advanced treatment. The purpose of this research is to test theeffectiveness of multi-layer filtration (MLF) performance with a detention time (td)of 12 hours and a combined SCW-MLF pumice reactor using yellow iris plants (Irispseudacorus) in treating domestic wastewater with 4 variations of detention time,namely 18, 12, 8 and 6 hours. The results of the analysis of the removal efficiencyand loading rate without plants with a td of 12 hours for the parameters of total N,Ammonia, Phosphate, Fatty Oil are 66.33%; 68.5%; 74.7%; 63.20% and 313.3-1000kg/Ha/day; 0.00025 0.00810kg/Ha/day; 0.0000169kg/Ha/day; 2088.95577.8kg/Ha/day. The most effective loading rate results from this research onSCW-MLF is td 12 hours with total N, ammonia, phosphate, and fatty oilparameters are 2.46- 2.50kg/Ha/day; 313.33- 313.33kg/Ha/day; 313.33-313.33kg/Ha/day; 2088.9 -2788.9kg/Ha/day. The most effective pumice adsorptioncapacity in the study of domestic wastewater followed the Freundlich isothermadsorption equation with R² values of 0.447 - 0.9978 at MLF td 12 hours and R²values of 6692 - 0.8803 at SCW- MLF td 12 hours. In this study, the SCW-MLFtreatment unit using yellow iris plants with a detention time of 12 hours can setaside the parameters of total N, ammonia, phosphate, and fatty oil so that it complieswith the quality standards of PERMEN LHK RI No. 68 of 2016.