T The medical industry currently has very high quality standards for medical products such as surgical sutures. PT XYZ, as a well-known manufacturer in this industry, faces challenges in reducing the level of surgical suture product defects. This research focuses on surgical suture products produced by PT XYZ. The problem was obtained from the results of surgical suture production which was carried out in the January to March period, during which period there was a fairly significant level of production defects. The aim of the research to be carried out is to improve the quality of surgical suture product packaging, namely to identify the causes of defects in the production process of surgical suture product packaging at PT. XYZ, identifies the stages of the packaging production process that are carried out in order to reduce defective packaging products and implement improvements and provide suggestions for improvements that can be made to PT\'s surgical suture packaging production process. XYZ. In this research, the Six Sigma method in the form of DMAIC will be used. At the Define stage, tools are used in the form of supplier, input, process, output and customer (SIPOC) diagrams and critical to quality (CTQ) identification. In the Measure stage there are calculations with the X bar R control chart, P control chart, C control chart as well as DPMO and sigma levels. At the analyze stage, analysis is carried out regarding the causes of failure using tools in the form of Pareto diagrams, fishbone diagrams, and failure mode effect analysis (FMEA). The next stage is Improve, where in the previous stage, namely FMEA, defects with the highest RPN were found in the form of torn cardboard, inappropriate color and damp cardboard. Therefore, cardboard defects need to be proposed for improvement using 5W 1H analysis. Based on the results of the 5W 1H analysis, it was found that alternative improvements for defects in torn cardboard, inconsistent color and damp cardboard were increasing the frequency of replacing cutting tools on mold cutting machines, using printing machine cleaning aids and improving factory environmental monitoring SOP. And an additional suggestion is in the form of antiseptic wet wipes in every cardboard packaging for surgical suture products. After the Improve stage, the final stage is carried out in the form of Control to see whether the implementation of the proposed improvements has a positive impact on the company. The implementation results stated that there was an increase in the sigma value to 3,670 sigma.