T he elderly population in Indonesia has increased from 18 million in 2010 to 27 million in 2020. Frailty syndrome is characterized by a decrease in the adaptive and functional functions of the body has an adverse impact on health such as disability and mortality. Loneliness is the second largest psychosocial problem among the elderly in Indonesia. Loneliness has an adverse impact on health such as fra`lity syndrome. The purpose of this study was to determine the relationship between loneliness and frailty syndrome in the elderly.METHODSThis study used a cross-sectional method with a total of 74 respondents selected through consecutive non-random sampling. Data collection was carried out in October and November 2023 at the 41 Al-Madinah Foundation Nursing Home. The measuring instrument used the Tilburg Frailty Indicator (TFI) questionnaire to measure frailty syndrome and the UCLA Loneliness scale version 3 for loneliness. Statistical analysis was performed using the Chi-square test and the level of significance used was <0.05.RESULTSThere were 64.9% lonely elderly and 62.1% frailty and pre-frailty elderly. There is a significant relationship between loneliness and frailty syndrome in the elderly (p<0.01). There is a relationship between sociodemographic characteristics with frailty syndrome, age (p=0.02) and gender (p=0.04).CONCLUSIONSThere is a significant association between age, gender and loneliness with frailty syndrome in the elderly.