W Within the last 5 years, there was an increased incidence of breast cancer in young women, including young women in the fields of health, although an early detection of breast cancer was discovered. Therefore, it is necessary to do research which aimed to determine the factors that affect the implementation of breast cancer early detection of female Trisakti University Medical School student, especially the correlation between breast cancer level of knowledge with implementation of breast cancer early detection on female Trisakti University Medical School student. This study is an observational analytic study which implemented in the Faculty of Medicine Trisakti University. This study used 120 samples, consisting of 60 class of 2010 and 60 in 2012. Data was collected using a questionnaire and then analyzed using univariate and bivariate analysis with Kolmogorov-Smirnov with the significance level is 0.05. The largest age distribution in this study were aged 21 years (58%) in the age group >= 20 years, and 19 years (60%) in the age categories <20 years. Most respondents have a good attitude towards early detection of breast cancer (n=103/85,8%), a good level of knowledge about breast cancer (n=91/75,8%) and less implementation of early detection of breast cancer (n=110/91,7%). Bivariate statistical test results showed there is no significant correlation between age and the implementation of early detection of breast cancer at the Faculty of Medicine, University of Trisakti student class of 2010 and 2012 (p = 0,978) , there was no significant correlation between attitudes (p = 0,819) and knowledge (p = 1,000) toward early detection of breast cancer with the implementation of early detection of breast cancer breast at Trisakti University Medical School student class of 2010 and 2012.