L Lower levels of performance-based physical function were associated with an increased risk of dementia and therefore suggested that poor physical function might in fact precede the onset of dementia. The purpose of this paper is to analyse and evaluate the effect of physical activity towards the cognitive function of university students; so that if there is any certain effect occurred in the middle of the research, the act of prevention can be conducted. The research is done by using cross-sectional method with total sample of 163 medicine students from Trisakti University. Furthermore, those samples arechosen by using consecutive non-random sampling method. Another points, levels of Physical function is measured with International Physical Activity Questioner (IPAQ), language ability with verbal fluency test, Executive function with Trial Making Test (TMT), and finally attention and memory with Digit Span test. The analysis of data is using SPSS version 22.0 for Mac OS 22.0 version and level of significance was set at 0.05. Kruskal-Wallis analysis shows the significant difference in each levels of physical activity group with the ability such as verbal fluency, executive function, attention,or even memory (p<0.001). Therefore, it is suggested that the higher the level of physical function, the higher students cognitive function might become. However,in regards to the executive function, there is no significant difference between medium and high levels of physical activity group. There is a relationship between the level of physical activity with the ability suchas verbal fluency, executive function, attention, and memory of the university student. As the result, students is suggested to conduct a high level of physical activity in their daily routine to prevent cognitive problems in the future.