A Among the biggest causes of root canal infections is the Streptococcus group. The body's reaction to prevent the spread of infection is an inflammatory reaction and an immunological reaction. If the spread of infection continues, then an acute condition occurs, so root canal treatment must be carried out immediately, which is one of the methods to keep the teeth in the mouth. The goal of root canal treatment is to remove the source of infection. The working principle of root canal treatment, working sterile and aseptic for both the operator, the tools used and the use of irrigation solutions. The use of irrigating solutions is to facilitate the removal of dead tissue and as a disinfectant in the root canal area. The irrigation solution used comes from the halogen group, including sodium hypochlorite and povidone iodine. Both of these materials have the same antiseptic power. Effect of irrigation solution Sodium hypochlorite at a concentration of 1% -5.25% is very effective in killing Streptococcus mutans and Streptococcus faecalis. While the effect of povidone-iodine at a concentration of 5\-10 is very effective in killing Streptococcus viridans. Both of these materials at concentrations of H, still have an antimicrobial effect to kill the bacteria that are present in the root canal.