D Dry eye is a multifactorial disease of the tears and the surface of the eye which results in symptoms of discomfort, visual disturbances, film instability which has the potential to cause damage to the surface of the eye. 1 In Southeast Asia, the prevalence of dry eye syndrome is relatively high, which is 20-52.4%.METHODThis research is an analytic observational study with a data collection method using a cross-sectional design with 150 respondents to online motorcycle taxi drivers in the Kebon Jeruk area, West Jakarta. Dry eyes were measured by the OSDI questionnaire. Bivariate analysis of smoke exposure duration and dry eye syndrome was assessed by chi-square test with a significance level of 0.05 using SPSS version 27.RESULTSIt was found that the sex of the respondents was mostly in the male category 98.67%, 86.0% were early adults, 78.67% had a duration of being on the road for more than 7 hours per day and online motorcycle taxi drivers who had dry eyes amounted to 79.3% of all research respondents. Bivariate analysis showed no relationship between age (p=0.122), gender (p=0.302) and duration of smoke exposure (p=0.096) and the occurrence of dry eye syndrome among online motorcycle taxi drivers.CONLUSIONThere is no significant relationship between the duration of smoke exposure and dry eye syndrome in online motorcycle taxi drivers