B one and jaw infections are painful for patients and frustrating for both them and their doctors. The high success rates of antimicrobial therapy in most infectious diseases have not yet been achieved in bone and jaw infections owing to the physiological and anatomical characteristic of bone. Osteomyelitis are acute and chronic. The key to successful management is early diagnosis, including bone sampling for microbiological and pathological examination to allow targeted and long lasting antimicrobiotherapy. The various types of osteomyelitis require deffering medical and surgical therapeutic strategies which are different. Chronic osteomyelitis is associated with avascular necrosis of bone and formation of sequestrum (dead bone), and surgical debridement is necessary for cure in addition antibiotic therapy.