T he OHIP-Edent and GOHAI questionnaires have been used to measure denture users’ quality of life in Indonesia. In Indonesia, there is still no study that compares the relationship of these questionnaires with dentures’ satisfaction. Methods: This type of research is a analytic-observational study with a cross-sectional design. It was carried out by distributing online questionnaires covering Jabodetabek region with a sample size of 89 respondents who used removable dentures and met the inclusion criteria. The OHIP-Edent and GOHAI scores were tested for their relationship with dentures’ satisfaction. Furthermore, the analytic test was performed using the Kruskall-Wallis and Mann-Whitney tests. Results: The percentage of the number of answers that had a significant impact on the OHIP-Edent questionnaire was higher than the GOHAI questionnaire, 27.71% and 23.15% respectively. The p value of the analytic test of the two questionnaires associated with dentures’ satisfaction level was <0.05, meaning a significant relationship. On the other hand, the analytic test between the two questionnaireswith the type of denture, the p value was >0.05, meaning an insignificant relationship. Conclusion: There is a significant relationship between the two questionnaires in measuring the quality of life associated with denture satisfaction, but the OHIP-Edent questionnaire results are better to capture dental impact than the GOHAI questionnaire.