B ACKGROUND In this ever changing era, the advancement of science and technology informationdevelops so fast that it creates a lot of qualified products so as to ease people’slife. Ironically, this also increases the incidence of Computer Vision Syndrome (CVS). This aim to this study is to determine the relationship between computeruse and the incidence of Computer Vision Syndrome (CVS). METHODS A cross-sectional observational study was conducted and a total of 234 studentswere included at Faculty of Medicine, University of Trisakti, West Jakarta. Datacollection was by questionnaire-based interviews. Data analysis was performedusing SPSS for Windows release 22.0 and level of significance was set at 0.05. RESULTS Chi-Square Analysis showed only an association between duration of computeruse (p =0.00) and the incidence of CVS, and there was no correlation between theeye break every hour of computer usage (p = 0.230), use of contact lenses (p =0.605) , the use of chair (p = 0.498), use of light (p = 0.604), use of a screen(p=0.251), the type of computer (p=0.686). CONCLUSIONS This study shows that extensive usage of computers are associated with theincidence of CVS at Trisakti University Faculty of Medicine students.