Profil nilai brain derived neurotrophic factor (bdnf) pada pria usia 18-30 tahun yang diberikan aktivitas fisik

DETAIL KOLEKSI

Profil nilai brain derived neurotrophic factor (bdnf) pada pria usia 18-30 tahun yang diberikan aktivitas fisik

Oleh : Kirana Restigaluh

Info Katalog

Penerbit : FK - Usakti

Kota Terbit : Jakarta

Tahun Terbit : 2025

Pembimbing 1 : Monica Dwi Hartanti

Kata Kunci : Brain-Derived Neurotrophic Factor (BDNF), muscle recovery, ELISA, Physical activity.

Status Posting : Published

Status : Lengkap

File Repositori

No.	Nama File	Hal.
1.	2025_SK_SKD_030002100083_Halaman-Judul.pdf
2.	2025_SK_SKD_030002100083_Surat-Pernyataan-Revisi-Terakhir.pdf	1
3.	2025_SK_SKD_030002100083_Surat-Hasil-Similaritas.pdf	1
4.	2025_SK_SKD_030002100083_Halaman-Pernyataan-Persetujuan-Publikasi-Tugas-Akhir-untuk-Kepentingan-Akademis.pdf	1
5.	2025_SK_SKD_030002100083_Lembar-Pengesahan.pdf	1
6.	2025_SK_SKD_030002100083_Pernyataan-Orisinalitas.pdf	1
7.	2025_SK_SKD_030002100083_Formulir-Persetujuan-Publikasi-Karya-Ilmiah.pdf	1
8.	2025_SK_SKD_030002100083_Bab-1.pdf
9.	2025_SK_SKD_030002100083_Bab-2.pdf
10.	2025_SK_SKD_030002100083_Bab-3.pdf
11.	2025_SK_SKD_030002100083_Bab-4.pdf
12.	2025_SK_SKD_030002100083_Bab-5.pdf
13.	2025_SK_SKD_030002100083_Bab-6.pdf
14.	2025_SK_SKD_030002100083_Bab-7.pdf
15.	2025_SK_SKD_030002100083_Daftar-Pustaka.pdf
16.	2025_SK_SKD_030002100083_Lampiran.pdf

Abstrak
Abstract

L LATAR BELAKANGAktivitas fisik memiliki manfaat besar bagi kesehatan fisik dan neuroprotektif.Latihan endurance, seperti kardio atau aerobik, meningkatkan kebugarankardiovaskular, aliran darah ke otak, serta merangsang molekul antioksidanseperti Superoxide Dismutase (SOD) yang melindungi sel saraf dan Brain-DerivedNeurotrophic Factor (BDNF), yang mendukung pertumbuhan dan diferensiasineuron. Namun, aktivitas fisik juga berisiko menyebabkan kerusakan ototterutama pada individu kurang aktif. Penelitian menunjukkan BDNF berperandalam pemulihan otot melalui pengaturan sel satelit. Namun, penelitian tersebutmasih terbatas pada hewan coba. Penelitian ini bertujuan untuk mengeksplorasipotensi serum BDNF sebagai penanda proses perbaikan otot pasca-latihan fisikpada pria usia 18-30 tahun yang jarang berolahraga.METODEPenelitian ini merupakan penelitan pra-experimental dengan one group pre andpost test yang menganalisis perubahan kadar Brain Derived Neurotrophic Factor(BDNF) pada 30 orang pria usia 18-30 tahun yang jarang berolahraga,.pengambilan sample dilakukan 3 kali, yaitu sebelum, segera setelah dan 72 jamsetelah aktivitas fisik endurance . Konsentrasi serum BDNF dianalisismenggunakan Kit ELISA dan akan dilakukan pembacaan dengan menggunakanELISA Reader. Uji normalitas yang digunakan adalah Shapiro wilk dan dianalisismenggunakan Reapeted Measure One Way ANOVA.HASILHasil menunjukkan mean kadar BDNF sebelum latihan 83,06 pg/ml dan segerasetelah latihan 87,33pg/ml dengan nilai P = 0,9331 dan terjadi peningkatansignifikan pada 72 jam setelah latihan dengan mean kadar BDNF 114,4 pg/ml dannilai P = 0,0422KESIMPULAN DAN SARANTidak terdapat perbedaan signifikan kadar BDNF pada sebelum dan segera setelahlatihan, namun terjadi peningkatan kadar BDND yang signifikan pada 72 jamsetelah latihan. Peningkatan ini mengindikasikan peran BDNF dalam prosesregenerasi otot melalui aktivitas sel satelit, yang penting untuk perbaikan ototpasca aktivitas fisik. BDNF berpotensi menjadi biomarker pemulihan otot

B BACKGROUNDPhysical activity has significant benefits for physical health andneuroprotection. Endurance exercises, such as cardio or aerobic workouts,enhance cardiovascular fitness, improve blood flow to the brain, and stimulateantioxidant molecules like Superoxide Dismutase (SOD) that protect nerve cells,as well as Brain Derived Neurotrophic Factor (BDNF), which supports the growthand differentiation of neurons. However, physical activity also carries the risk ofcausing muscle damage, particularly in individuals who are less active. Researchindicates that BDNF plays a role in muscle recovery through the regulation ofsatellite cells. Nonetheless, these studies have primarily been limited to animalmodels. This research aims to explore the potential of serum BDNF as a markerfor muscle repair processes following physical activity in men aged 18-30 whoengage in infrequent exercise.METHODSThis research employs a pre-experimental design with a one-group pre-test andpost-test approach, analyzing changes in BDNF levels among 30 male participantsaged 18-30 years. Blood samples were collected three times: before exercise,immediately after, and 72 hours following endurance physical activity. SerumBDNF concentrations were assessed using an ELISA kit, with readings taken viaan ELISA reader. Normality was tested using the Shapiro-Wilk test, and data wereanalyzed using Repeated Measures One Way ANOVA.RESULTSThe results indicated a mean BDNF level of 83.06 pg/mL before exercise, whichincreased to 87.33 pg/mL immediately after exercise (p = 0.9331). A significantincrease was observed at 72 hours post-exercise, with a mean BDNF level of114.4 pg/mL (p = 0.0422).CONCLUSION AND RECOMMENDATIONSThere was no significant difference in BDNF levels between pre-exercise andimmediately post-exercise; however, a significant increase was noted at 72 hourspost-exercise. This increase suggests the role of BDNF in muscle regenerationthrough satellite cell activity, which is crucial for muscle recovery followingphysical stress. BDNF has potential as a biomarker for muscle recovery.