S Soursop plant is widely cultivated in the culture of Indonesia. Apart from its delicious taste, this plant is also widely employed as an anti-cancer agent, especially its leaves. Besides its exploitation as anti-cancer agent, it can also be used as an antifungal, antiinflammation, and anti-bacterial agent. One of the bacteria that cause abnormalities in the oral cavity with high prevalence is Porphyromonas gingivalis. These bacteria cause periodontal disease such as gingivitis and periodontitis. This study aims to determine the ratio of the effect of leaf extract of Annona muricata in the fraction of ethanol and ethyl acetate against the inhibition growth zone of Porphyromonas gingivalis. The researchmethod is divided into two phases, phase extraction and inhibition zone test phase. In the extraction phase, the extract was fractioned into fractions of ethanol and fractions of ethyl acetate. In the inhibition zone test phase, using a jelly diffusion plate which would then measure rhe diameter of inhibitory zone. The results of this study indicate that the fraction of 10% ethanol, 20% and 40% have an average diameter of inhibition zone respectively 11.38 mm, 16.33 mm and 13.125 mm. While the ethyl acetate fraction of 10%, 20% and 40% yield an average diameter of inhibition zone of 12.83 mm, 17.75 mmand 14.25 mm. The result of this research is processed by one way ANOVA test and produce the value of p <0.05, which means that there are significant differences in the test material. So that in this study it can be concluded that the extract of the leaves of Annona muricata ethyl acetate fraction produce inhibition zone diameter greater than the fraction of ethanol, and the best concentration is the concentration of 20% ethyl acetate extract.