A According to data from the World Health Organization (WHO) the annual prevalence rate of migraine is 12% and is included in the third most common medical disease and the second neurological disorder. Several factors that influence this are demographic factors (age and gender) and psychological workload on employees. There is still controversy between several studies related to psychological workload and the incidence of migraine in employees. Therefore, this study aims to determine the relationship between psychological workload and the incidence of migraine among employees at Ministry X.METHODThis study used a cross-sectional study with a total of 257 respondents at the Coordinating Ministry for Economic Affairs. Data collection by questionnaire (CarMen-Q, MS-Q, and sociodemographic data). Data analysis was carried out using the Chi-Square method through the SPSS program with a significance level of 0,05.RESULTMost of the respondents were in the age category of 26-35 years (45.9%), male (52.5%). Respondents with a high psychological workload of 46.7%. Migraine incidence rate among employees is 43.6%. The results of the bivariate analysis showed that there was a relationship between gender (p < 0.001), psychological workload (p < 0.001), and the incidence of migraine. However, there was no relationship between age and the incidence of migraine (p = 0.457).CONCLUSIONThere is a relationship between gender and psychological workload with the incidence of migraines in employees. However, there is no relationship between age and the incidence of migraine in employees