B Background: Tooth extraction procedures cause alveolar bone resorption. Application of the Bovine Amniotic Membrane-Hydroxyapatite (BAM-HA) biocomposite is expected to have a role as an alveolar bone socket preservation material. Alveolar bone socket regeneration is characterized by the proliferation of osteoblasts and osteocytes in the process of bone remodeling. Purpose: To analyze the histological image of the number of osteoblast and osteocyte cells proliferation in the alveolar bone socket of Sprague dawley rats on the 14th and 28th days with application of BAM-HA biocomposite after tooth extraction. Research method: A total of 30 SD rats were extracted from the lower right I1 teeth and divided into 5 treatment groups, including biocomposite BAM-HA 40:60, 35:65, 30:70, application of Bio-Oss collagen as a positive control, and without treatment as a negative control. After 14 and 28 days, the rats were euthanized and histological image were made with hematoxylin eosin staining to calculate the proliferation of osteoblast and osteocyte cells. The data in the study were analyzed using a two way ANOVA test followed by Tukey’s post-hoc test. Result: Histological appearance of osteoblasts and osteocytes was seen in all groups. The number of osteocyte cells increased on day 14 and decreased on day 28, while osteocyte cells continued to increase from day 14 to day 28. Osteoblasts and osteocytes were higher in the group with material application than without material application in the alveolar bone socket after tooth extraction (p<0.05). Statistical results showed that there was no significant difference in the number of osteoblasts and osteocytes in the BAM-HA group with different ratios (p>0.05). Conclusion: The application of BAM-HA as biocomposite can improve regeneration in the alveolar bone sockets of SD rats which can be seen from the growth of osteoblasts and osteocytes.