C Composite resin restoration materials is widely used in dentistry. One of the important mechanical properties is the compressive strength, because of the existence of the loads caused. Composite resins have been widely used in comparison with other materials for posterior teeth restoration. There are two techniques application for composite resins incremental and bulkfill. The aim of this research is to determine the differences in compressive strength of nanohybrid composite resin materials and packable bulkfill composite resin on 2 mm and 4 mm thickness. This research uses the acrylic mold diameter of 2 mm with 2 mm and 4 mm thickness. There are 20 samples of composite resin and were divided into 4 groups. Group I packable bulkfill composite resins 2 mm thickness, group II packable bulkfill composite resin 4 mm thickness, group III nanohybrid composite resin 2 mm thickness and Group IV nanohybrid composite resins 4 mm thickness. Each sample done polymerization with intensity of 1000 mW/cm" and incubated for 24 hours. A universal testing machine (UTM) were used to test their compressive strength. Data were analyzed using Two Way Anova. The results showed there are significant differences between the groups of variables i.e. p = 0,013 (p < 0.05). The differences in compressive strength of nanohybrid composite resin materials and packable bulkfill composite resin on 2 mm and 4 mm thickness is the conclusion of this research. Packable bulkfill composite resin with 2 mm thickness has the most excellent compressive strength compared to other groups.