T The Cikopo-Palimanan Toll Road is a toll road that connects the Cikopo area, Purwakarta District with the Palimanan area, Cirebon District. In this toll road, there are 4 rest areas towards Cirebon and 4 rest areas towards Jakarta. With the location of the exisiting rest area, will it be able to overcome the fatigue of the drivers on the toll road. It’s necessary to evaluate the fatigue of drivers on the Cikopo-Palimanan toll road. The purpose of this study is to find out the factors that cause driver fatigue on the Cikopo-Palimanan toll road and to find out is the location of the exisiting rest area able to overcome the fatigue of the drivers. The reasearch was conducted by descriptive observation using purposive sampling technique with a survey method using questionnaire and then distributed to drivers who stopped at the rest area KM 86 and KM 130 Cikopo-Palimanan toll road. The data is processed using SPSS Software and Microsoft Excel. From these results, it’s found that the factors that cause fatigue on the Cikopo-Palimanan toll road are congestion, geometric conditions of the road that tend to be straight, and the road pavement conditions. The result of the analysis of the location of the exisiting rest areas related to the ability to overcome the drivers fatigue are that the KM 86 and KM 130 rest areas have exceeded the limit to to eliminate mild, moderate, and severe fatigue.