G Growth factor is a general term used to denote a class of naturally occurring proteins that function in the body to promote mitogenesis, directed migration and metabolic activity of cells. Growth factor to mediate repair and regeneration the periodontium. A combination of growth factor may more effectively stimulate these diverse processes of regeneration than single growth factor. Combination platelet derived growth factor (PDGF) and insulin-like growth factor-1 (IGF-1), significant amounts of newly formed bone and new sementum. PDGF and transforming growth factor-beta (TGF-beta) are known to be abundant in the alfa granules of platelets. Currently the use of Platelet Rich Plasma (PRP) into a bone graft combination showed a significant gain in periodontal regeneration. It is probable that, it’s used to promote periodontal regeneration.