T The occurence of divorce in Indonesia has increased. Premarital counseling is needed as away to prevent or lower the number of divorce. Premarital counseling is also a program thatinvolves to-be-married couples. This program aims to counsel, educate, and prepare them tostart a family. It is also important to prevent genetic or congenital disorder, and otherpsychology-social disorder. This prevention is conducted by doing premarital healthexamination. The interest in doing it requires a good knowledge about it. METHODS A cross-sectional study was conducted and a total of 83 staffs at Kantor Sekretariat KabinetRepublik Indonesia. Data collection was done using interview-based questionnaire. Dataanalysis was performed using SPSS 21.0 on windows computer with level of significancewas set at 0,05. RESULT Chi-square analysis showed a correlation between knowledge and interest in doing premaritalcheck-up with p values 0,002 or p<0,05, which means there is a significant correlationbetween both variables.CONCLUSIONThis study revealed a significant correlation between knowledge and interest in doing premarital check-up in reproductive age.