B ackground: Quality of life could well be affected by oral mucosal diseases suchas acute and chronic oral lesions. OHRQoL is a tool that could assess whether oraldiseases impair a person's quality of life. OHIP-14 and COMDQ-26 are two of theOHRQoLs that have been frequently used. Objective: To analyze the quality of lifeusing the COMDQ-26 and OHIP-14 indices in patients with acute and chronic orallesions. Methods: This study used analytic observational research using a crosssectionaldesign. Examining oral lesions and completing the OHIP-14 andCOMDQ-26 questionnaires were conducted to 30 subjects. Pearson's correlationwas used to analyze data. Results: The item reliability for the Indonesian versionof the COMDQ-26 was 0.92 and the Cronbach alpha was 0.83. COMDQ-26score 31 (24-53) and OHIP-14 score 8 (2-25) were observed in acute oral lesions(n=7), whereas 32 (13-73) and 5 (0-33) were present in chronic oral lesions (n=23).There was no correlation between the type of oral lesions and the OHRQoLquestionnaires (p>0.05), however it was found that the COMDQ-26 domain and theOHIP-14 domain were significantly correlated (p<0.05), with the exception of thefinding that COMDQ-26 domain 4 was not associated to any of the OHIP-14domain (p>0.05). Conclusion: Despite having strong construct validity, theIndonesian version of the COMDQ-26 remains unable to differentiate between theimpact of quality of life based on the nature of an oral lesion. The use of theIndonesian version of the COMDQ-26 has to be confirmed by additionalinvestigation.