H igh levels of blood cholesterol is a major factor in cardiovascular disorders . The decrease in the hormone estrogen in postmenopausal women can result in elevated levels of cholesterol in the blood than premenopausal women . Batak people often consume foods high in cholesterol and alcohol at the reception customs , so that a risk of hypercholesterolemia Batak tribe. Research conducted an observational analytic cross sectional design involving 30 premenopausal women and 30 postmenopausal women . Data were collected by interview using a questionnaire that included age , education level , marital status , occupation , age of menarche , lifestyle , diet and body mass index (BMI) . Measurement of total cholesterol level is done by blood sampling technique through capillary blood vessels. The result showed that there were significant differences in total cholesterol levels between premenopausal and postmenopausal woman in Batak tribe (p = 0,024). Factors of studied, in premenopausal women significant relationship with total cholesterol levels and body mass index (p = 0,002). postmenopausal women there is a significant correlation with total cholesterol levels body mass index (p = 0,000). This study shows significant differences in total cholesterol levels in premenopausal and postmenopausal women in the Batak tribe . Postmenopausal women cholesterol levels > 200 mg / dl more than the total cholesterol levels of premenopausal women.