Q uality of life is an individual\'s response to life, taking into account the cultural background and value system of their environment. In children, quality of life assesses all health care, especially chronically ill children. Children living with smoking parents are likely to be exposed to cigarette smoke. Low birth weight, not being given breast milk, poor nutrition, and not being immunized are risks for pneumonia. Exposure to cigarette smoke and the risk of pneumonia in children is one of the factors that influences quality of life. This study aims to determine the relationship between exposure to cigarette smoke and the risk of pneumonia with children quality of lifeMETHODSObservational analytical study with cross-sectional approach involving 92 women (15-49 years) in Posyandu RW 07 and RW 15, Kelurahan Menteng Atas, South Jakarta. Data were collected with Fagerstorm Test for Nicotine Dependence (FTND) questionnaire for exposure to cigarette smoke (independent variable), risk of pneumonia (independent variable), and Pediatric Quality of Life Generic Core Scale 4.0 (PedsQl) for quality of life (dependent variable). Data analysis used the Chi-square test with a significance level of 0,05RESULTSThe results of this study show that there is a relationship between exposure to cigarette smoke and children\'s quality of life (p=0,000) and there is a relationshio between the risk of pneumonia and children\'s quality of life (p=0,003)CONCLUSIONSThere is a correlation between exposure to tobacco smoke and the risk of pneumonia with the quality of life of children