B BACKGROUND Tuberculosis (TB) is a infectious disease caused by the bacteria Mycobacterium tuberculosis that was discovered in 1882 by microbiologists, Robert Koch.2 Direct supervision of treatment and therapy is done to ensure patient compliance in the treatment due to the need to take medication for 6 months.2 Patient's adherence in the treatment will reduce the transmission of tuberculosis to people. To achieve healing of patients, they need social support from the nearest family members in order not to be uninterested and not to forget.3 METHOD This research uses an observational analytic study with cross sectional design with total respondents of 137 people at in Dr. Mintohardjo Navy Hospital at Central Jakarta. Collected data with questionaire were given to the respondents based on inclusion and exclusion criteria. Analysis of the data using Chi Square test with SPSS (Statistical Product and Service Solutions) series 20.0 for Windows. RESULT Based on the distribution of subject characteristics of respondents, the majority of them were male (59.1%) aged 15-24 years (22.6%), with a duration of treatment 5-6 months (29.9%) and respondents with high school educational level (69,3%). There is a relationship between family support and adherence of Anti Tuberculosis Medication, resulting from the Chi Square analysis test with p value = 0.027. CONCLUSION There is a relationship between family support with adherence in medication of anti tuberculosis in Navy Hospital by Dr. Mintohardjo