I Indonesia has the largest nickel reserves in the world, making it a very important country in the world\\\'s supply of nickel raw materials. Nickel-containing minerals are often finely dispersed throughout the ore, therefore it is difficult to increase the nickel content in the ore economically without losing other significant content. The world\\\'s large use of nickel has led to the reduction of high-grade nickel deposits, therefore it is necessary to increase the low nickel content by hydrometalurgy process, one of which is the flotation process. In this research using limonite nickel ore with particle size -200#, solid percent 20%, oleic acid collector dose 664 g/ton, frother pine oil 85 gr/ton, and pH 10. The variables analyzed were depressant dose 1000 gr/ton, 1500 gr/ton, 2000 gr/ton with flotation time 5 minutes, 10 minutes, 15 minutes. The results of this research show that the depressant dose and flotation time greatly influence the effectiveness of the flotation separation process. The highest nickel content was obtained in the flotation tailings sample with a depressant dose of 2000 gr/ton and a time of 15 minutes at 2.20%. The highest recovery value obtained from the flotation process was the use of a depressant dose of 1000 gr/ton and a flotation time of 15 minutes with a recovery value of 78.54%.