B Background: Porphyromonas gingivalis is one of the bacteria that cause pulp necrosis, this bacteria can be eliminated through endodontic treatment either mechanically by using instruments or chemically through irrigation solutions. NaOCl is an irrigation solution that has become the gold standard in endodontic treatment, however NaOCl is toxic, so other alternative materials are needed. One usable material is papaya plant (Carica papaya L.) which has antibacterial compounds such as flavonoids, alkaloids, tannins, papain enzymes, saponins, and others. The research objective: to know the differences in the activity of papaya leaves extract, papaya seed extract, and papaya fruit juice (Carica papaya L.) in inhibiting Porphyromonas gingivalis. Methods: This study was a laboratory experimental study which was done in vitro with a well agar diffusion method. The extracts of papaya seeds and papaya leaves were obtained by the maceration method with 96% ethanol solvent, while papaya fruit was juiced with a juicer. Papaya seed extract, papaya leaves extract, and papaya fruit juice were then diluted with akuades to obtain concentration of 6.25%, 12.5%, 25%, 50%, and 100%. Results: This study showed that the diameter of inhibitory zone against Porphyromonas gingivalis was found on 2 concentrations of papaya seed extract, a concentration of 100% with an average 23,43 mm and concentration of 50% with an avarege 16,43 mm. The results of the Shapiro-Wilk test statistics obtained that data were normally distributed (p> 0.05), then continued with One-way Anova and Post Hoc Tukey which showed a significant difference (p <0.05). The inhibition zone test of papaya leaves extract and papaya fruit juice against Porphyromonas gingivalis bacteria was not found around the well. Conclusion: Papaya seed extract was able to inhibit Porphyromonas gingivalis in certain concentration, while papaya leave extract and papaya fruit juice were not able to inhibit the growth of Porphyromonas gingivalis.