B Background: Clinically establishing a diagnosis for oral lesions is challenging due to many lesions having similar clinical presentations, leading to potential errors. It is crucial for dental students, as future practitioners, to possess sufficient knowledge for accurate diagnosis. Accuracy in clinically detecting and diagnosing lesions is necessary to prevent the progression of lesions to a more invasive stage, guide the selection of appropriate therapies, and improve the prognosis of diseases. Objective: To determine the accuracy level of oral lesion detection and diagnosis through clinical photos by profession program students at Trisakti University's Faculty of Dentistry and the influencing factors. Methods: An analytical observational study was conducted on 100 professional program students. Respondents were gathered in one room to fill out a questionnaire containing clinical photos of oral lesion cases through the Google Form application. The responses of professional program students from the questionnaire were tabulated into a 2x2 table and calculated using sensitivity, specificity, and kappa tests to determine accuracy levels. Results: Profession program students demonstrated a good accuracy level in detection at 88.55% with a kappa value of 0.66132, while the accuracy level in diagnosis was 38.21% with a kappa value of -0.30446. Male students found it easier to detect lesions, whereas female students were more adept at diagnosis. Linear regression analysis was conducted to examine the influence of the GSM 6515 module and GPA on the ability to detect and diagnose, showing statistically significant results. Conclusion: The accuracy level of oral lesion detection by professional program students is substantial agreement, while the diagnosis level of oral lesions by students is poor agreement. The GSM 6515 module score plays a role in professional program students' ability to detect oral lesions. GPA plays a role in professional program students' ability to diagnose oral lesions.