D Defecation is one of the least studied human function. Many survey-based studies suggest that the frequency of defecation of normal population has a range from three times per week to three times per day. There are many factors that can influence the pattern of defecation. One of the factor that can cause changes in the pattern of defecation is nicotine, which has been known to have a number of adverse effects on organ systems, including the respiratory, cardiovascular, renal innervation, endocrine and metabolic systems, and last is gastrointestinal. Therefore, departing from the nicotine effects on gastrointestinal function described above, the high rate of smokers in productive age, a lack of exploration of non-infectious factors that play a role in changing patterns of defecation in Indonesia, the author of this research wants to find a relationship between degree of smoking and pattern of defecation. This research uses an observational analytic study with a cross-sectional design which include 118 smokers who is in their productive age in RW 02, Kelurahan Tomang, Jakarta Barat. The data were collected by interview using the form of smoking degree, frequency of defecation, and stool consistency to determine the degree of smoking, frequency of defecation and changes in stool consistency. The Data then analysed using SPSS for mac version 24.0 and the level of significance used is 0.05. The result of bivariate data analysis were carried out by using the chi-square test. It was found that 3 subjects (4.4%) had mild smoking degree with abnormal frequency of defecation, and 9 subjects (18.0%) had moderate to severe smoking degree with abnormal frequency of defecation. There was also found that 5 subjects (7.4%) mild smoking degree with abnormal stool consistency, and 14 subjects (28.0%) with moderate to severe smoking degree with abnormal stool consistency. This study shows that there is a significant relationship between the degree of smoking and the pattern of defecation in smokers of productive age.