B Bacterial pathogen which is found in periodontal tissues is Porphyromonas gingivalis as the anaerobic bacteria found in subgingival area. In addition to mechanical technique it can also be done by using chemical ingredient such as using mouthwash, but it gained a lot of side effects of mouthwash chemicals which has a negative impact to the body. The effect can be minimized by using medication derived from nature. One of the natural substances that can be used is an extract of papaya leaves (Carica papaya L.). The purpose of this experiment was to determine the effectiveness of the ethanol extract of papaya leaves to inhibit the growth of Porphyromonas gingivalis. The research sample was using the ethanol extract of papaya leaves which were diluted to five dilutions to 50%, 25%, 12.5%, 6.25%, 3.125%, and Porphyromonas gingivalis bacterial. The study was conducted using the agar disk diffusion method with the positive control was chlorhexidine 0.2% and negative control was distilled water. Observations were made during 3x24 hours to observe the inhibition of diameter zone which formed of translucent wide circle around the test material. The diameter of inhibition zone which had the largest of inhibitory zone is at the dilution of 6.25% with the results 24.48 mm and the smallest inhibitory zone is at the dilution of 3.125% with the results 23.13 mm. It can be concluded that the ethanol extract of papaya leaves is effective for inhibiting the growth of Porphyromonas gingivalis.