Lesi oral terkait reaksi hipersensitivitas dan autoimun yang dipicu oleh infeksi sars-cov-2 dan vaksin covid-19 (systematic review)
Nomor Panggil : 616.31 SAL l
Penerbit : FKG - Usakti
Kota Terbit : Jakarta
Tahun Terbit : 2025
Pembimbing 1 : Indrayadi Gunardi
Pembimbing 2 : Rahmi Amtha
Subyek : Oral Medicine
Kata Kunci : SARS-CoV-2, hypersensitivity, autoimmune, oral
Status Posting : Published
Status : Lengkap
No. | Nama File | Hal. | Link |
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1. | 2025_SK_SIG_040002100104_Halaman-Judul.pdf | 11 | |
2. | 2025_SK_SIG_040002100104_Surat-Pernyataan-Revisi-Terakhir.pdf | 1 | |
3. | 2025_SK_SIG_040002100104_Surat-Hasil-Similaritas.pdf | 1 | |
4. | 2025_SK_SIG_040002100104_Halaman-Pernyataan-Persetujuan-Publikasi-Tugas-Akhir-untuk-Kepentingan-Akademis.pdf | 1 | |
5. | 2025_SK_SIG_040002100104_Lembar-Pengesahan.pdf | 1 | |
6. | 2025_SK_SIG_040002100104_Pernyataan-Orisinalitas.pdf | 1 | |
7. | 2025_SK_SIG_040002100104_Formulir-Persetujuan-Publikasi-Karya-Ilmiah.pdf | 1 | |
8. | 2025_SK_SIG_040002100104_Bab-1.pdf | ||
9. | 2025_SK_SIG_040002100104_Bab-2.pdf |
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10. | 2025_SK_SIG_040002100104_Bab-3.pdf |
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11. | 2025_SK_SIG_040002100104_Bab-4.pdf |
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12. | 2025_SK_SIG_040002100104_Bab-5.pdf |
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13. | 2025_SK_SIG_040002100104_Bab-6.pdf |
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14. | 2025_SK_SIG_040002100104_Bab-7.pdf | ||
15. | 2025_SK_SIG_040002100104_Daftar-Pustaka.pdf | ||
16. | 2025_SK_SIG_040002100104_Lampiran.pdf |
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L Latar belakang: COVID-19, yang disebabkan oleh SARS-CoV-2, ditetapkansebagai sebuah pandemi, sehingga mendorong beberapa ilmuan untuk menelitivaksinnya. Infeksi dan vaksin COVID-19 dilaporkan dapat memicu reaksihipersensitivitas dan autoimun di rongga mulut. Hingga kini, belum ada systematicreview (SR) yang secara khusus membahas reaksi ini di dalam rongga mulut padapasien pasca infeksi atau vaksin COVID-19. Tujuan: Mengetahui profil dankeparahan, durasi onset, medikamen dan respon terapi lesi oral hipersensitivitas danautoimun setelah terpapar virus atau vaksin COVID-19. Metode: Penelitianobservasional deskriptif menggunakan database PubMed, Scopus, dan SageJournal dari tahun 2020-2023. Analisis SR menggunakan Microsoft Excel. Hasil:Penelitian ini menganalisis sebanyak 41 artikel dengan mayoritas pasien perempuan(67.86%). Vaksin COVID-19 lebih sering memicu lesi oral autoimun, terutama orallichen planus (OLP) (76.53%), dibandingkan infeksi COVID-19 (5.77%), yangcenderung memicu lesi oral hipersensitivitas, terutama erythema multiforme (EM)(58.33%). Lesi oral autoimun memiliki durasi onset yang lebih panjang dan lebihrentan mengalami eksaserbasi pasca vaksinasi daripada lesi oral hipersensitivitas.Terapi utama untuk lesi oral ini adalah kortikosteroid. Kesimpulan: Hasil SRmenunjukkan bahwa vaksin COVID-19 sering memicu lesi oral meskipun kasusserupa juga ditemukan pada beberapa pasien pasca terinfeksi SARS-CoV-2. Dalamkasus yang jarang, vaksin dapat memperburuk lesi, tetapi tetap dapat diberikan jikaditangani dengan tepat.
I Introduction: COVID-19, caused by SARS-CoV-2, was declared a pandemic,prompting researchers to study its vaccine. Both COVID-19 infection andvaccination have been reported to trigger hypersensitivity and autoimmunereactions in the oral cavity. To date, no systematic review (SR) has specificallyaddressed these reactions in the oral cavity of patients exposed to COVID-19infection or vaccine. Objective: This study aims to investigate the profile, severity,onset duration, medication, and response to therapy of these oral hypersensitivityand autoimmune lesions following exposure to the COVID-19 virus or vaccine.Methods: A descriptive observational study using PubMed, Scopus, and SageJournal databases from 2020-2023. SR analysis was performed using MicrosoftExcel. Results: This study analyzed 41 articles with majority of patients beingfemale (67.86%). COVID-19 vaccination tends to trigger oral autoimmune lesions,particularly oral lichen planus (OLP) (76.53%), than COVID-19 infection, whichmore commonly induces oral hypersensitivity-related lesions, especially erythemamultiforme (EM) (58.33%). Oral autoimmune lesions have a longer onset durationand are more prone to exacerbation following vaccination than oral hypersensitivitylesions. The first-line therapy of these oral lesions is corticosteroid. Conclusion:SR results indicate that the COVID-19 vaccine frequently triggers oral lesionsalthough similar lesions have been reported in some patients with COVID-19 postinfection. In rare cases, the vaccine may exacerbate lesions, but it can still beadministered if done appropriately.