Uji pH dan viskositas formulasi obat kumur yang mengandung air perasan zingiber officinale var. officinale
L Latar belakang: Air perasan Zingiber officinale var. officinale memiliki banyak manfaat. Salah satunya sebagai campuran obat kumur. Tujuan: Menganalisis perbedaan formulasi obat kumur yang mengandung air perasan Zingiber officinale var. officinale konsentrasi 3,125%, 6,25%, dan 12,5% terhadap nilai pH dan viskositas pada hari ke-0, 14, 28, 42, dan 56. Metode: Perasan Zingiber officinale var. officinale konsentrasi 3,125%, 6,25%, dan 12,5% dicampurkan dengan propilen glikol, PEG-40 hydrogenated castor oil, oleum menthae, asam benzoat, natrium benzoat, kalsium laktat, sorbitol 70% dan kalsium tiosianat. Formulasi tersebut diukur nilai pH dengan pH meter (Jenway, United Kingdom) dan viskositas dengan viskometer (Brookfield, Massachusetts) selama 56 hari. Data pH dianalisis dengan uji GLM Repeated Measures ANOVA dan One Way ANOVA (p<0,05). Data viskositas dianalisis dengan uji GLM Repeated Measured ANOVA dan Kruskal Wallis (p<0,05). Hasil: Nilai pH formulasi obat kumur 3,125% berbeda signifikan selama 56 hari dengan rentang 5,50-5,61. Nilai viskositasnya tidak berbeda signifikan selama 56 hari dengan rentang 3,03-3,09 cP. Formulasi obat kumur 6,25% mempunyai nilai pH dan viskositas yang tidak berbeda signifikan selama 56 hari dengan nilai pH 5,78-5,83, sedangkan nilai viskositasnya yaitu 3,12-3,13 cP. Nilai pH dan viskositas formulasi obat kumur 12,5% tidak berbeda signifikan selama 56 hari dengan nilai pH 4,90-4,97, sedangkan nilai viskositasnya yaitu 3,43-3,50 cP. Kesimpulan: Formulasi obat kumur Zingiber officinale var. officinale 3,125% mempunyai nilai pH yang tidak stabil, tetapi mempunyai nilai viskositas terendah dan stabil selama 56 hari. Formulasi 6,25% dan 12,5% memiliki nilai pH dan viskositas yang stabil selama 56 hari. Nilai pH tertinggi pada formulasi 6,25%.
B Background: Zingiber officinale var. officinale juice has many benefits. It can be used as a mixture of mouthwash. Objective: To analyse the difference of Zingiber officinale var. officinale mouthwashes 3,125%, 6,25%, and 12,5% on pH and viscosity values on day 0,14,28,42, and 56. Method: Zingiber officinale var. officinale 3,125%, 6,25%, and 12,5% is mixed with propylene glycol, PEG-40 hydrogenated castor oil, oleum menthae, benzoic acid, sodium benzoate, calcium lactate, sorbitol 70% and calcium thiocyanate. The formulation has measured with pHmeter (Jenway, United Kingdom) and viscometer (Brookfield, Massachusetts) for 56 days. The pH data is analysed using GLM Repeated Measures ANOVA and One-Way ANOVA (p<0,05). Viscosity data is analysed using GLM Repeated Measured ANOVA and Kruskal Wallis (p<0,05). Results: The pH value of 3,125% formulation shows significant difference for 56 days in range 5,50-5,61. The viscosity value shows no significant difference for 56 days in range 3,03-3,09 cP. The pH and viscosity values of 6,25% formulation shows no significantly different for 56 days with 5,78-5,83 pH value, while the viscosity is 3,12-3,13 cP. The pH and viscosity values of the 12,5% formulation shows no significantly different for 56 days with 4,90-4,97 pH value, while the viscosity is 3,43-3,50 cP. Conclusion: Zingiber officinale var. Officinale mouthwash formulations 3,125% has been unstabled, but it has the lowest viscosity value and has been stabled for 56 days. The pH and viscosity values of 6,25% and 12,5% formulations have been stabled for 56 days. The highest pH value is in the formulation of 6,25%.