I Inflammation and proliferative growth of epithelial cells of the oral mucosa can be either a neoplastic process such as a papilloma or a non-neoplastic process such as gingival enlargement and gingival polyps. Immunohistochemical examination is used to detect proliferation, cell differentiation, gene mutations and tissue vascularization and helps to understand the biologic nature of the lesion. This study aims to determine the relationship between the intensity of inflammatory cells with epithelial cell proliferation and expression of the .K.i-67+ gene in gingival polyps, gingival enlargement and squamous cell papillomas. This study was a laboratory study with a cross-sectional design using samples from excision of the gingiva and oral mucosa which were clinically diagnosed as gingival enlargement due to hormones and chronic irritation (n=4); gingival polyps (n=3) ; and papillomas (n=3). The intensity of the inflammatory set was seen from the number of inflammatory cells in one area by H.E staining with lOx magnification. Epithelial cells are called K.i-6T when there is a brown color in the nucleoplasm. The Ki-6T set index is calculated by dividing the number of positive cells by the total number of sets in one field of view with 400x magnification. The biserial correlation test showed that inflammatory cells with a percentage of positive cells had a weak negative correlation (r=-0.315<0.4), inflammatory cells with a state of epithelial proliferation had a weak correlation (r=0.218<0.4), a state of epithelial cell proliferation with index score Ki-67+ with a weak negative correlation (r=-0.361<0.4). Thus it can be concluded that the intensity of inflammatory cells with epithelial proliferation and expression of the proliferative gene Ki-6T in neoplastic and non-neoplasmic lesions shows a Jemah correlation. The intensity of inflammatory cells does not correlate with an increase in Ki-67.