F Formation of normal cell into mutant cell can be caused by several factors (multifactorial). These factors alter the normal function of genes that regulate the cell cycle. In biomolecular there are two groups of genes that play a role in cancer cell growth, namely oncogenes and tumor suppressor genes. Oncogene in normal circumstances is a proto-oncogene that function to induce cell cycle at a more advanced stage to justify the cell to proceed from one stage to the next cell cycle. Normal cell cycle becomes dysregulated due to the mutation of proto-oncogene (into oncogene) and tumor suppressor gene that lead to cellular transformation. The tumor suppressor gene that in normal condition inhibits progression of the cell cycle become inactive and causes uncontrolled cell division.