Etiologi dan patogenesis sumbing palatinum pada sindrom pierre robin (Studi Pustaka)
S Sumbing palatum pada sindrom pierre Robin (PRS) dapat berbentuk U dan V namun umumnya berbentuk U. Manifestasi PRS dalam mulut dan kraniofasial meliputi hipoplasia mandibula, sumbing palatum, dan glossoptosis yamg sering menyebabkan masalah pada saluran napas. Patogenesis sumbing palatum padaPRS karena faktor genetik dimana terjadi gangguan pada perkembangan mandibula (mikrognasia) yang mencegah pergerakan normal dari lidah ke arah bawah sehingga mencegah fusi normal dari palatum. Akibatnya, lidah terdorong ke belakang (glossoptosis), menyebabkan hambatan jalan napas.
C Cleft palate in the pierre Robin Syndrome (PRS) found as U and V-shaped cleft, however the form of cleft palate in PRS are more likely U-shaped. Manifestations in the oral and craniofacial of PRS include mandibular hypoplasia, cleft palate, and glossoptosis which often caused problem in the airway obstruction. Genetically, pathogenesis of cleft palate in PRS occurs due to a disturbance in the development of the mandible (micrognathia) that prevents normal movement of the tongue toward the bottom thereby preventing normal fusion of the palate. As the result, the tongue can be pushed to the back, causing airway obstruction.