Hubungan antara kadar interleukin-6 dan kejadian mortalitas pada pasien COVID-19

DETAIL KOLEKSI

Hubungan antara kadar interleukin-6 dan kejadian mortalitas pada pasien COVID-19

Oleh : Ceyvira Arsita Widaryati

Info Katalog

Nomor Panggil : S 2038

Penerbit : FK - Usakti

Kota Terbit : Jakarta

Tahun Terbit : 2023

Pembimbing 1 : Ida Effendi

Subyek : Interleukin-6;COVID-19 (Disease)

Kata Kunci : interleukin 6 levels, mortality, COVID-19, age, gender

Status Posting : Published

Status : Lengkap

File Repositori

No.	Nama File	Hal.
1.	2023_TA_SKD_030001900029_Halaman-Judul.pdf	15
2.	2023_TA_SKD_030001900029_Pengesahan.pdf	1
3.	2023_TA_SKD_030001900029_BAB-1_Pendahuluan.pdf	4
4.	2023_TA_SKD_030001900029_BAB-2_Tinjauan-Literatur.pdf	21
5.	2023_TA_SKD_030001900029_BAB-3_Kerangka-Teori.pdf	3
6.	2023_TA_SKD_030001900029_BAB-4_Metode-Penelitian.pdf	8
7.	2023_TA_SKD_030001900029_BAB-5_Hasil.pdf	3
8.	2023_TA_SKD_030001900029_BAB-6_Pembahasan.pdf	6
9.	2023_TA_SKD_030001900029_BAB-7_Kesimpulan.pdf	1
10.	2023_TA_SKD_030001900029_Daftar-Pustaka.pdf	2
11.	2023_TA_SKD_030001900029_Lampiran.pdf	24

Abstrak
Abstract

V Virus COVID-19 menginfeksi manusia melalui saluran pernafasan hingga dapat menyebabkan mortalitas. Banyak faktor yang menyebabkan tingginya angka mortalitas akibat COVID-19 ini. Badai sitokin adalah salah satu kondisi di mana terjadi respon lebih sistem imun tubuh melalui pelepasan sitokin IL-6 yang sangat memengaruhi kondisi klinis pasien COVID-19 serta dapat menyebabkan mortalitas pada pasien COVID-19. Tujuan penelitian ini adalah untuk mengetahui hubungan antara kadar IL-6 dan kejadian mortalitas pada pasien COVID-19.METODEPenelitian ini menggunakan metode observasional analitik dengan pendekatan cross sectional. Penelitian ini dilakukan secara Consecutive Sampling. Pengumpulan data dilakukan dari rekam medik pasien COVID-19. Hubungan antara variabel dianalisis dengan uji Chi Square dalam program SPSS (Statistikal Package for the Social Sciens) menggunakan analisis univariat dan bivariat.HASILDari 336 responden, terdapat 61,6% pasien laki-laki, 46,4% pasien berusia â‰¥60 tahun, 37,8% pasien memiliki kadar interleukin antara 7,01-80 pg/ml, dan pasien didominasi oleh pasien yang meninggal sebanyak 60,4%. Hasil Chi-square didapatkan hubungan yang bermakna antara Kadar interleukin 6 (p=0,000) dan mortalitas pada pasien COVID-19, dan hubungan yang bermakna antara usia dan mortalitas pada pasien COVID-19(p=0,000), serta terdapat hubungan yang bermakna pula antara jenis kelamin dan mortalitas pada pasien COVID-19(p = 0,000).KESIMPULANPada penelitian ini didapatkan hasil adanya hubungan antara kadar interleukin 6 dan kejadian mortalitas pada pasien COVID-19. Didapatkan pula hubungan antara usia, jenis kelamin dan mortalitas pada pasien COVID-19.

T The COVID-19 virus infects humans through the respiratory tract and can cause death. Many factors cause the high mortality rate from COVID-19. Cytokine storm is one of the conditions where there is an over response of the body's immune system through the release of IL-6 cytokines which greatly affects the clinical condition of COVID-19 patients and can cause mortality in COVID-19 patients. The aim of this study was to determine the relationship between IL-6 levels and the incidence of mortality in COVID-19 patients.METHODThis study used an analytic observational method with a cross sectional approach. This research was conducted by Consecutive Sampling. Data collection was carried out from the medical records of COVID-19 patients. The relationship between variables was analyzed using the Chi Square test in the SPSS (Statistical Package for the Social Sciences) program using univariate and bivariate analysis.RESULTSThe results of the study obtained from 336, there were 61.6% of male patients, 46.4% of patients aged â‰¥60 years, 37.8% of patients had interleukin levels between 7.01- 80 pg/ml, and patients were dominated by who died as much as 60.4%. Chi-square results found a significant relationship between interleukin 6 levels (p=0.000) and mortality in COVID-19 patients, and a significant relationship between age and mortality in COVID-19 patients, and there was also a significant relationship between gender and mortality in COVID-19 patients. (p = 0.000).CONCLUSIONIn this study, the results showed that there was a relationship between interleukin 6 levels and the incidence of mortality in COVID-19 patients. A relationship was also found between age, sex and mortality in COVID-19 patients.