DETAIL KOLEKSI

Efek antibakteri kombinasi natrium hipoklorit dengan esomeprazole terhadap pertumbuhan enterococcus faecalis dan escherichia coli


Oleh : Aurellia Nadia Cendana

Info Katalog

Nomor Panggil : 615.1 AUR e

Penerbit : FKG - Usakti

Kota Terbit : Jakarta

Tahun Terbit : 2021

Pembimbing 1 : Didi Nugroho Santosa

Subyek : Bacterial infection;Sodium hypochlorite

Kata Kunci : sodium hypochlorite, esomeprazole, antibacterial effect, enterococcus faecalis, escherichia coli


File Repositori
No. Nama File Ukuran (KB) Status
1. 2021_TA_KG_040001800024_Halaman-Judul.pdf 667.12
2. 2021_TA_KG_040001800024_Lembar-Pengesahan.pdf 290.4
3. 2021_TA_KG_040001800024_Bab-1_Pendahuluan.pdf 226.86
4. 2021_TA_KG_040001800024_Bab-2_Tinjauan-Pustaka.pdf 500.47
5. 2021_TA_KG_040001800024_Bab-3_Kerangka-Teori,-Kerangka-Konsep,-dan-Hipotesis.pdf 220.71
6. 2021_TA_KG_040001800024_Bab-4_Metode-Penelitian.pdf 824.22
7. 2021_TA_KG_040001800024_Bab-5_Hasil-Penelitian.pdf 735.26
8. 2021_TA_KG_040001800024_Bab-6_Pembahasan.pdf 334.34
9. 2021_TA_KG_040001800024_Bab-7_Kesimpulan-dan-Saran.pdf 65.51
10. 2021_TA_KG_040001800024_Daftar-Pustaka.pdf 445.91
11. 2021_TA_KG_040001800024_Lampiran.pdf 966.96

L Latar belakang: Penghambat pompa proton merupakan obat yang digunakan untuk mengobati gangguan sekresi asam lambung dengan cara menghambat pompa proton secara selektif dan ireversibel. Penelitian terdahulu menyatakan bahwa dengan penambahan penghambat pompa proton pada natrium hipoklorit memiliki efek antibakteri yang lebih tinggi. Penelitian ini dilakukan terhadap Enterococcus faecalis dan Escherichia coli yang memiliki pompa proton. Tujuan: Untuk mengetahui efek antibakteri kombinasi natrium hipoklorit 5,25% dengan esomeprazole terhadap pertumbuhan E. faecalis dan E. coli. Metode: Penelitian ini merupakan penelitian in vitro dengan rancangan penelitian post-test only control design yang dilakukan di Laboratorium MiCORE FKG Universitas Trisakti. Dilakukan enam perlakuan terhadap E. faecalis dan E. coli. Enam kelompok perlakuan tersebut adalah esomeprazole 4%, esomeprazole 8,5%, omeprazole 8,5% kombinasi natrium hipoklorit 5,25%, esomeprazole 8,5%, natrium hipoklorit 5,25%, dan akuades. Hasil: Pada perlakuan esomeprazole 8,5%, kombinasi NaOCl 5,25% dengan omeprazole 8,5%, dan akuades tidak ditemukan zona hambat pada kedua bakteri. Didapatkan nilai rerata zona hambat terhadap E. faecalis sebagai berikut, larutan kombinasi esomeprazole 4% (16,18 mm (SD±1,60)), kombinasi esomeprazole 8,5% (14,20 mm (SD±0,21)), dan NaOCl 5,25% (25,90 mm (SD±1,46)). Terhadap E. coli didapatkan nilai rerata zona hambat sebagai berikut, kombinasi esomeprazole 4% (16,68 mm (SD±1,68)), kombinasi esomeprazole 8,5% (13,87 mm (SD±0,07)), dan NaOCl 5,25% (30,22 mm (SD±1,08)). Kesimpulan: Larutan kombinasi natrium hipoklorit dengan esomeprazole tidak lebih baik dibandingkan natrium hipoklorit 5,25% dalam menghambat pertumbuhan bakteri E. faecalis dan E. coli.

B Background: Proton pump inhibitors are drugs used to treat gastric acid secretion disorders by selectively and irreversibly inhibiting the proton pump. Previous studies have shown that the addition of proton pump inhibitors to sodium hypochlorite has a higher antibacterial effect. This research was conducted on Enterococcus faecalis and Escherichia coli which have proton pumps. Objective: To examine the antibacterial effect of the combination of NaOCl 5,25% with esomeprazole on the growth of E. faecalis and E. coli. Methods: This study is an in vitro research with a post-test only control design. The research was done at the MiCORE Laboratory of Trisakti University Faculty of Dentistry. There were six treatments for E. faecalis and E. coli. The six treatment groups were esomeprazole 4%, esomeprazole 8.5%, omeprazole 8.5% combined with NaOCl 5.25%, esomeprazole 8.5%, NaOCl 5.25%, and aquades. Results: In the treatment of esomeprazole 8.5%, combination of NaOCl 5.25% with omeprazole 8.5%, and aquades shown that no inhibition zones were found in both bacteria. The average value of the inhibition zone against E. faecalis was as follows, esomeprazole 4% combination (16.18 mm (SD±1,60)), esomeprazole 8,5% combination (14.20 mm (SD±0,21)), and NaOCl 5,25% (25.90 mm (SD±1,46)). Against E. coli, the average inhibition zone values were obtained as follows, esomeprazole 4% combination (16.68 mm (SD±1,68)), esomeprazole 8,5% combination (13.87 mm (SD±0,07)), and NaOCl 5.25% (30.22 mm (SD±1,08)). Conclusion: The combination of sodium hypochlorite with esomeprazole was not better than 5,25% sodium hypochlorite in inhibiting bacterial growth of E. faecalis and E. coli.

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