M Mastrotto Indonesia (PT) is a manufacturing company engaged in the field of leather tanning, specialized in producing leather for automotive industry needs. This research is focused on the cutting process because it is the most important part in PT Mastrotto Indonesia’s production process. The objectives of this research to identify and to reduce the risks of musculoskeletal disorders (MSDs) experienced by the operator. The symptoms complaint of MSDs risk arises when the operator puts a pattern on the table by squatting and it is proven from the results of the Nordic Body Map questionnaires given to the operator. The identification of the initial condition of operator working posture uses software modelling of JACK 8.2 with Virtual Environment and Virtual Human methods according to the real system condition. The used tools for measuring are Static Strength Prediction, Low Back Analysis, Ovako Working Analysis System, Rapid Upper Limb Assessment and the evaluation results using Posture Evaluation Index (PEI). The operators analyzed in this research consist of Operator 1, Operator 2 and Operator 3 who have different job description, with the body height of (169±1,4) cm and the body weight of (73,75±2,5) Kg. Operator 1 and operator 2 have the task of putting a pattern on the table, while operator 3 gives a pattern to operator 1 and operator 2. This research results in the new work station size and design adjusted with operator anthropometric data. The proposed improvement is to change the work station contained in the cutting process. The results of identification before the improvement according to PEI score for Operator 1, Operator 2, Operator 3 are 2,81, 2,85 and 2,43, after the improvement of work station the PEI score becomes 1,52, 1,53 and 1,12. It is expected that this research can reduce the symptoms of musculoskeletal disorder risk in the cutting operator of PT Mastrotto Indonesia.