DETAIL KOLEKSI

Efek antibakteri kombinasi natrium hipoklorit dengan berbagai konsentrasi lansoprazoleterhadap enterococcus faecalis dan escherichia coli


Oleh : Gabriella Geralda Santjoko

Info Katalog

Nomor Panggil : 615.1 GAB e

Penerbit : FKG - Usakti

Kota Terbit : Jakarta

Tahun Terbit : 2022

Pembimbing 1 : Didi Nugroho Santosa

Subyek : Sodium hypochlorite;Bacterial infection

Kata Kunci : sodium hypochloride, lansoprazole, antibacterial effects, enterococcus faecalis


File Repositori
No. Nama File Ukuran (KB) Status
1. 2022_TA_KG_040001800056_Halaman-Judul.pdf 1037.98
2. 2022_TA_KG_040001800056_Lembar-Pengesahan.pdf 296.45
3. 2022_TA_KG_040001800056_Bab-1_Pendahuluan.pdf 224.76
4. 2022_TA_KG_040001800056_Bab-2_Tinjauan-Pustaka.pdf 1272.11
5. 2022_TA_KG_040001800056_Bab-3_Kerangka-Teori,-Konsep,-Hipotesis.pdf 5.39
6. 2022_TA_KG_040001800056_Bab-4_Metode-Penelitian.pdf 1073.39
7. 2022_TA_KG_040001800056_Bab-5_Hasil-Penelitian.pdf 820.74
8. 2022_TA_KG_040001800056_Bab-6_Pembahasan.pdf 499.28
9. 2022_TA_KG_040001800056_Bab-7_Kesimpulan-dan-Saran.pdf 61.84
10. 2022_TA_KG_040001800056_Daftar-Pustaka.pdf 538.83
11. 2022_TA_KG_040001800056_Lampiran.pdf 1509.39

L Latar belakang: Pada Perawatan Saluran Akar (PSA), tindakan irigasi memegang peranan penting atas keberhasilan PSA. Natrium hipoklorit yang merupakan baku emas larutan irigasi, tidak bersifat bakterisid terhadap Enterococcus faecalis, penyebab utama kegagalan PSA. Bakteri ini dapat bertahan hidup karena memiliki pompa proton, yang dapat dijumpai pula pada Escherichia coli. Penelitian ini dilakukan menggunakan kombinasi natrium hipoklorit dengan obat Proton Pump Inhibitor (PPI) generasi terbaru yaitu lansoprazole. Tujuan: Mengetahui efek antibakteri kombinasi natrium hipoklorit dengan berbagai konsentrasi lansoprazole terhadap Enterococcus faecalis dan Escherichia coli. Metode: Penelitian eksperimental laboratorium in vitro dengan metode difusi yang dilaksanakan di laboratorium MiCORE FKG Universitas Trisakti. Variabel bebas yang digunakan terdiri atas natrium hipoklorit 5,25% kombinasi lansoprazole 4% dan 8,5%, lansoprazole 8,5%, natrium hipoklorit 5,25% kombinasi omeprazole 8,5%, natrium hipoklorit 5,25%, dan akuades. Hasil: Tidak ditemukan adanya zona hambat E. faecalis dan E. coli pada lansoprazole 8,5%, natrium hipoklorit 5,25% kombinasi omeprazole 8,5%, dan akuades. Zona hambat E. faecalis dan E. coli terbentuk pada natrium hipoklorit 5,25% kombinasi lansoprazole 4%, natrium hipoklorit 5,25% kombinasi lansoprazole 8,5%, dan natrium hipoklorit 5,25%. Nilai rerata zona hambat E. faecalis berturut-turut adalah 14,4±2,10 mm, 10,89±0,68 mm, dan 25,9±1,46 mm. Sedangkan, pada E. coli adalah 19,48±2,48 mm, 10,89±0,76 mm, dan 30,22±1,10 mm. Kesimpulan: Efek antibakteri kombinasi natrium hipoklorit 5,25% dengan lansoprazole 4% dan kombinasi natrium hipoklorit 5,25% dengan lansoprazole 8,5% kurang efektif dibandingkan dengan efek antibakteri natrium hipoklorit 5,25% terhadap Enterococcus faecalis dan Escherchia coli

B Background: Sodium hypochloride (NaOCl), which is the gold standard for irrigation solutions, has low bactericidal activity against Enterococcus faecalis, the main cause of root canal treatments failure. This resistance due to its proton pump, which can also be found in Escherichia coli. This research was conducted using a combination of NaOCl with lansoprazole, the latest generation proton pump inhibitor. Objective: To determine the antibacterial effect of the combination of NaOCl with various concentrations of lansoprazole against E. faecalis and E. coli. Method: Laboratory experimental research in vitro with the diffusion method which was carried out in the MiCORE laboratory, Faculty of Dentistry, Universitas Trisakti. The independent variables were 5.25% NaOCl combination of 4% and 8.5% lansoprazole, 8.5% lansoprazole, 5.25% NaOCl combination of omeprazole 8.5%, 5.25% NaOCl and aquadest. Results: There was no inhibition zone of E. faecalis and E. coli in lansoprazole 8.5%, NaOCl 5.25% combination of omeprazole 8.5%, and aquadest. Inhibition zones of E. faecalis and E. coli were formed in 5.25% NaOCl combination of 4% lansoprazole, 5.25% NaOCl combination of 8.5% lansoprazole, and 5.25% NaOCl. The mean value of the inhibition zone of E. faecalis were 14,4±2,10 mm, 10,89±0,68 mm, and 25,9±1,46 mm respectively. Meanwhile, the mean value of the inhibition zone of E. coli were 19,48±2,48 mm, 10,89±0,76 mm, dan 30,22±1,10 mm. Conclusion: The antibacterial effect of 5.25% NaOCl combination of 4% and 8.5% lansoprazole was less effective than the antibacterial effect of 5.25% NaOCl.

Bagaimana Anda menilai Koleksi ini ?