C Cisadane River is a river that crosses from Bogor Regency to Tangerang Regency, human activities around the river can cause an increase in pollutant loads. Pollutant load capacity research was carried out on the Cisadane River starting from the Teuku Umar Bridge, Tangerang City to Muara Tanjung Burung, Tangerang Regency with a research time starting from March-June 2021. The purpose of this study was to calculate and determine the concentration of nitrate and phosphate in water, and to determine the flow conditions in the middle Cisadane River through the distribution pattern of parameter concentration by simulating the Qual2Kw method. The method used to identify pollutant sources is carried out by conducting field surveys, water quality analysis is carried out according to the spectrophotometer method and compared with the quality standards according to PP. 22 of 2021, as well as analysis of the pollutant load capacity (DTBP) of nitrate, and phosphate using the QUAL2Kw model. The results of the identification of potential pollutant sources in the Cisadane River are dominated by settlements, agriculture, industry, and other domestic activities, namely restaurants and stalls. The results of water quality analysis for nitrate parameters ranged from 0,17 mg/L– 0,99 mg/L, and phosphate ranged from 0,2 mg/L–1,3 mg/L. When compared with PP No.22 of 2021, the nitrate parameter is still below the quality standard, while the phosphate parameter has exceeded the quality standard. The nitrate pollutant load ranged from 7270,56 kg/day–9971,19 kg/day, and the phosphate pollutant load ranged from 3417,16 kg/day–10296,82 kg/day. The carrying capacity of the nitrate pollutant load ranged from 74992,92 kg/day–110672,64 kg/day, the phosphate pollutant load capacity ranged from 1454,11 kg/day–2225,66 kg/day. The capacity of the Cisadane River can still receive nitrate contamination but the phosphate pollutant load exceeds its capacity